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Participants were derived on average 3.35 pounds for each four-year period to weight gain to a weight gain from 16.8 pounds above 20 – year time period.. The investigators change in the more specific lifestyle factors and increase in weight four years through 12 to 20 follow-up separate separate large cohorts, the Nurses ‘ Health Study , the Nurses’ Health Study II and the Health Professionals Follow up study . The last analysis integrated 50,422 female within the NHS, 898 female the NHS II and 22,557 male to HPFS , all of whom preponderance obesity or chronic disease beginning of the study.