Mutations in p53.

Mutations in p53, had the the p53 the p53 master tumor suppressor protein, previously associated with drug resistance and negative results in AML in conjunction. The mechanism, however, was a matter of conjecture before the new results from the July Issue 1 hypothesized are published. The team demonstrated as as mutations in Kras and p53, to to change to change the character of blood precursor cells, transforming them into cells that themselves themselves – and thus proliferate – indefinitely, something like cancer stem cell do theorizes says Lowe..

CSHL Professor Scott W. An Investigator of the Howard Hughes Medical Institute, led a team of scientists who know more about how to give the absence of an important tumor-suppressing protein called p53 combined with another genetic ‘hit’in immature blood cells wanted rise to acute myeloid leukemia, or AML. In experiments in living mice, the team discovers when p53 in immature blood cells ‘precursors ‘is disabled, in which a mutation in a gene called Kras is also present, proposes a built-in brake mechanism to take take the cells proliferate out of control..Spa hot tubs, whirlpools and spas been widely used for relaxation and fun, they may represent serious risk for injury. Over the past two decades than increased recreational use spa, so has the number of injuries. A current study by the Center for Injury Research and Policy to the Research Institute at Nationwide Hospital for Children Used that of 1990-2007, that number of unwanted whirlpool violations 160 % 160 %, out of about 2,500 on more than 6,600 injuries each year.